Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population

  • Sima SABBAGH Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Zakiye NADEALI 1. Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran 2. Medical Genetics Laboratory, Al-Zahra University Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
  • Leila DEHGHANI Department of Tissue Engineering and Regenerative Medicine, School of Advanced Technologies in Medicine, Shahid Beheshti Uni-versity of Medical Sciences, Tehran, Iran
  • Vahid SHAYGANNEJAD Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Majid REZVANI Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Masih SABOORI Department of Neurosurgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Hamid GANJI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Soheil TAHANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Farzaneh DEHGHANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Saman HOSSEINZADEH Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Elnaz MARZBANI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
  • Peiman SHAFIEI Isfahan Neurosciences Research Center, Al-Zahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
Keywords: Multiple sclerosis; MMP-9 gene; Polymorphism; Association study

Abstract

Abstract Background: Matrix metalloproteinase-9 (MMP-9) polymorphisms, C−1562 T and -90 (CA) n repeats, which influence transcriptional activity of this gene, are proposed to play a role in MS susceptibility and its development. In the present study, the possible association of MMP-9 polymorphisms in Iranian MS patients is studied. Methods: Association of MMP-9 mentioned gene polymorphisms with MS susceptibility was evaluated in unrelated Iranian subjects referred to Al-Zahra Hospital, Isfahan, Iran during 2014 to 2017.  Results: -1562 T allele of MMP-9 was associated with increased MS risk. However, we found no overall significant effect of −90 (CA)n repeat on MS susceptibility. Conclusion: For as much as MMP-9 molecule is a potential target for MS therapy, to determine whether any of MMP-9 polymorphisms influence MS susceptibility in Iranian MS patients or not, concerning the significant influence of T allele on MS susceptibility and the non-significant association regarding CA repeats, further research is needed before proposing any definite conclusion.  

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Published
2019-09-03
How to Cite
1.
SABBAGH S, NADEALI Z, DEHGHANI L, SHAYGANNEJAD V, REZVANI M, SABOORI M, GANJI H, TAHANI S, DEHGHANI F, HOSSEINZADEH S, MARZBANI E, SHAFIEI P. Association Study between Functional Polymorphisms of MMP9 Gene Promoter and Multiple Sclerosis Susceptibility in an Iranian Population. Iran J Public Health. 48(9):1697-1703.
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Original Article(s)