Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article

  • Faezeh SHABANI AZIM Student Scientific Research Center, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  • Hamidreza HOURI Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Zohreh GHALAVAND Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Bahram NIKMANESH Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran, 2-Dept. of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
Keywords: Next generation sequencing, Cancer, Genetic diagnosis, Biomarkers, Personalized medicines

Abstract

Abstract Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine. Methods: Scientific databases were searched to collect relative data. Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor- normal comparisons can be performed using NGS in order to diagnosis of several types of cancer. Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner.  

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Published
2018-10-06
How to Cite
1.
SHABANI AZIM F, HOURI H, GHALAVAND Z, NIKMANESH B. Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article. IJPH. 47(10):1453-7.
Section
Review Article(s)