Association of rs3787016 in Long Non-coding RNAs POLR2E and rs2910164 in MiRNA-146a with Prostate Cancer: A Systematic Review and Meta-analysis
AbstractBackground: The aim of this study was to conduct a meta-analysis to estimate the association between the two SNPs and PCa risk.Methods: Medline, Embase, Scopus, PubMed, Web of Science, Wan Fang Database and Chinese Zhi Wang Database were searched for the association of the two SNPs with susceptibility to PCa. The effect size was pooled by odds ratios (ORs) and 95% confidence intervals (95% CIs).Results: Nine case-control studies, 5 on rs3787016 and 4 on rs2910164, were included. As regards rs3787016, an increased risk of PCa was identified in all genotype models (T versus C: OR = 1.18, 95% CI 1.11-1.25; CT versus CC: OR = 1.17, 95% CI 1.08-1.26; TT versus CC: OR = 1.41, 95% CI 1.22-1.63; TT + CT versus CC: OR = 1.20, 95% CI 1.12-1.30; TT versus CT + CC: OR = 1.32, 95% CI 1.15-1.52). However, no significant association was found between rs2910164 and PCa risk in any genetic models, in fact a trend of reduced risk could be seen (C versus G: OR = 0.91, 95% CI 0.79-1.05; GC versus GG: OR = 0.93, 95% CI 0.74-1.18; CC versus GG: OR = 0.70, 95% CI 0.47-1.02; CC + GC versus GG: OR = 0.90, 95% CI 0.73-1.12; CC versus GC + GG: OR = 0.78, 95% CI 0.56-1.08). Besides, in analysis of subgroups by source of controls, the decreased results were observed in studies using population-based controls.Conclusion: lncRNA POLR2E polymorphism rs3787016 is associated with a significantly increased risk of PCa, while a trend of reduced risk appears with mir-146a polymorphism rs2910164.
Cao DL, Gu CY, Zhu Y et al (2014). Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population. Prostate Cancer Prostatic Dis, 17(4): 315-9.
Siegel R, Naishadham D, Jemal A (2013). Cancer statistics, 2013. CA Cancer J Clin, 63(1): 11-30.
Chen M, Zhou ZY, Chen JG et al (2014). Effect of miR-146a polymorphism on biochemical recurrence risk after radical prostatectomy in southern Chinese population. Genet Mol Res, 13(4): 10615-21.
Crawford ED (2009). Understanding the epidemiology, natural history, and key pathways involved in prostate cancer. Urology, 73(5): S4-10.
Prensner JR, Iyer MK, Sahu A et al (2013). The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet, 45(11): 1392-8.
Wu K, Liu J, Tseng SF et al (2014). The role of DAB2IP in androgen receptor activation during prostate cancer progression. Oncogene, 33(15): 1954-63.
Sun J, Zheng SL, Wiklund F et al (2008). Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12. Nat Genet, 40(10): 1153-5.
Thomas G, Jacobs KB, Yeager M et al (2008). Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet, 40(3): 310-5.
Jin G, Sun J, Isaacs SD et al (2011). Human polymorphisms at long non-coding RNAs (lncRNAs) and association with prostate cancer risk. Carcinogenesis, 32(11): 1655-9.
Nikolic ZZ, Brajuskovic GN, Pavicevic D et al (2013). Assessment of possible association between rs3787016 and prostate cancer risk in Serbian population. Int J Clin Exp Med, 6(1): 57-66.
Xu T, Zhu Y, Wei QK et al (2008). A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma. Carcinogenesis, 29(11): 2126-31.
Nikolic ZZ, Savic Pavicevic D, Vukotic VD et al (2014). Association between genetic variant in hsa-miR-146a gene and prostate cancer progression: evidence from Serbian population. Cancer causes control, 25(11): 1571-5.
George GP, Gangwar R, Mandal RK et al (2011). Genetic variation in microRNA genes and prostate cancer risk in North Indian population. Mol Biol Rep, 38(3): 1609-15.
Hashemi M, Moradi N, Ziaee SA et al (2016). Association between single nucleotide polymorphism in miR-499, miR-196a2, miR-146a and miR-149 and prostate cancer risk in a sample of Iranian population. J Adv Res, 7(3): 491-8.
Moher D, Liberati A, Tetzlaff J et al (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med, 151(4):264-9.
Higgins JP, Thompson SG (2002). Quantifying heterogeneity in a meta-analysis. Stat Med, 21(11): 1539-58.
Borenstein M, Hedges LV, Higgins JP et al (2010). A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods, 1(2): 97-111.
Begg CB, Mazumdar M (1994). Operating characteristics of a rank correlation test for publication bias. Biometrics, 50(4): 1088-101.
Egger M, Davey Smith G, Schneider M et al (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109): 629-34.
Li K, Tie H, Hu N et al (2014). Association of two polymorphisms rs2910164 in miRNA-146a and rs3746444 in miRNA-499 with rheumatoid arthritis: a meta-analysis. Hum Immunol, 75(7): 602-8.
Xu B, Feng NH, Li PC et al (2010). A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivo. Prostate, 70(5): 467-72.
Kojima S, Goto Y, Naya Y (2017). The roles of microRNAs in the progression of castration-resistant prostate cancer. J Hum Genet, 62(1):25-31.
Bartel DP (2009). MicroRNAs: target recognition and regulatory functions. Cell, 136(2): 215-33.
Gutschner T, Diederichs S (2012). The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol, 9(6): 703-19.
Wang J, Liu X, Wu H et al (2010). CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer. Nucleic Acids Res, 38(16): 5366-83.
Hauptman N, Glavac D (2013). Long non-coding RNA in cancer. Int J Mol Sci, 14(3): 4655-69.
Yoshimoto R, Mayeda A, Yoshida M et al (2016). MALAT1 long non-coding RNA in cancer. Biochim Biophys Acta, 1859(1): 192-9.
Jazdzewski K, Murray EL, Franssila K et al (2008). Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci U S A, 105(20): 7269-74.
Ma XP, Zhang T, Peng B et al (2013). Association between microRNA polymorphisms and cancer risk based on the findings of 66 case-control studies. PloS One, 8(11): e79584.
Xu Y, Gu L, Pan Y et al (2013). Different effects of three polymorphisms in MicroRNAs on cancer risk in Asian population: evidence from published literatures. PloS One, 8(6): e65123.
He B, Pan Y, Cho WC et al (2012). The association between four genetic variants in microRNAs (rs11614913, rs2910164, rs3746444, rs2292832) and cancer risk: evidence from published studies. PloS One, 7(11): e49032.
Easterbrook PJ, Berlin JA, Gopalan R et al (1991). Publication bias in clinical research. Lancet, 337(8746): 867-72.
Reed AE, Chan L, Mikels JA (2014). Meta-analysis of the age-related positivity effect: age differences in preferences for positive over negative information. Psychol Aging, 29(1): 1-15.