Effects of Different Spectral Energy Distributions on Physiological Behavior and Hormone Levels in Depression
AbstractBackground: The increasing worldwide incidence of depression causes massive economic losses to the country and society. Insufficient sun exposure aggravates depressive symptoms in patients with depression. Preventive light replenishment is provided to patients with depression and the potential population. In addition, we studied the applicable spectrum, which is crucial in the prevention of depression.Methods: Forty depressed male rats were randomly divided into five groups of 8 rats each: depressive model, microwave sulfur lamp, halogen lamp, fluorescent lamp, and LED lamp groups. Rats in the illuminated groups were exposed to light for 45 days for 2 h daily. Eight healthy rats were selected for the control group. The body weight and general behaviors of rats were recorded. After the experiment, peripheral blood was collected from the tail vein, and the concentrations of MT, 5-HT, NA, and BDNF in serum were detected by ELISA.Results: After the model was established, the body weight of rats in the depressive model group increased slowly. Compared with those of the control group, the results of the three behavioral tests were significantly different (P<0.05); the contents of MT, 5-HT, NA, and BDNF were relatively low (P<0.05). In addition, depression characteristics were significant. Rats regained their pleasant sensation after microwave sulfur lamp intervention. Compared with the rats in the depressive model group, the levels of MT, 5-HT, NA, and BDNF increased sharply.Conclusion: The spectral energy distribution of microwave sulfur lamp is similar to the solar spectrum, which can alleviate depressive symptoms in depressed rats.
Kennedy SH (2006). A review of antidepressant treatments today. Eur Neuropsychopharm, 16:S619-S23.
Holsboer F (2000). The corticosteroid receptor hypothesis of depression. Neuropsychopharmacolgy, 23(5):477-501.
Patten SB, Williams JVA, Lavorato DH, et al. (2017). Seasonal variation in major depressive episode prevalence in canada. Epidemiol Psychiatr Sci , 26(2):169-76.
Kurlansik SL, Ibay AD (2012). Seasonal affective disorder. Am Fam Physician, 86(11):1037-41.
Magnusson A, Boivin D (2003). Seasonal affective disorder: An overview. Chronobiol Int, 20(2):189-207.
Guzel Ozdemir P, Boysan M, Smolensky MH, et al. (2015). Comparison of venlafaxine alone versus venlafaxine plus bright light therapy combination for severe major depressive disorder. J Clin Psychiatry, 76(5):e645-54.
Sahlem GL, Kalivas B, Fox JB, et al. (2014). Adjunctive triple chronotherapy (combined total sleep deprivation, sleep phase advance, and bright light therapy) rapidly improves mood and suicidality in suicidal depressed inpatients: An open label pilot study. J Psychiatr Res, 59:101-07.
Figueiro MG, Plitnick BA, Lok A, et al. (2014). Tailored lighting intervention improves measures of sleep, depression, and agitation in persons with alzheimer's disease and related dementia living in long-term care facilities. Clin Interv Aging, 9:1527-37.
de Bodinat C, Guardiola-Lemaitre B, Mocaer E, et al. (2010). Agomelatine, the first melatonergic antidepressant: Discovery, characterization and development. Nat Rev Drug Discov, 9(9):743-43.
Alan JG MP, John CM,et al. (2010). Practice guideline for the treatment of patients with major depressive disorder, 3rd ed. American Psychiatric Association, Washington DC.
Lewy AJ, Wehr TA, Goodwin FK, et al. (1980). Light suppresses melatonin secretion in humans. Science, 210(4475):1267-69.
Lewy AJ, Kern HA, Rosenthal NE, et al. (1982). Bright artificial-light treatment of a manic-depressive patient with a seasonal mood cycle. Am J Psychiatry, 139(11):1496-98.
Berson DM, Dunn FA, Takao M (2002). Phototransduction by retinal ganglion cells that set the circadian clock. Science, 295(5557):1070-73.
Rosenthal NE, Sack DA, Gillin JC, et al. (1984). Seasonal affective-disorder - a description of the syndrome and preliminary findings with light therapy. Arch Gen Psychiatry, 41(1):72-80.
Schwartz PJ, Brown C, Wehr TA, et al. (1996). Winter seasonal affective disorder: A follow-up study of the first 59 patients of the national institute of mental health seasonal studies program. Am J Psychiatry, 153(8):1028-36.
LeGates TA, Altimus CM, Wang H, et al. (2012). Aberrant light directly impairs mood and learning through melanopsin-expressing neurons. Nature, 491(7425):594-98.
Vandewalle G, Schwartz S, Grandjean D, et al. (2010). Spectral quality of light modulates emotional brain responses in humans. Proc Natl Acad Sci USA, 107(45):19549-54.
Warthen DM, Wiltgen BJ, Provencio I (2011). Light enhances learned fear. Proc Natl Acad Sci USA, 108(33):13788-93.
Kripke DF (2015). A breakthrough treatment for major depression. J Clin Psychiatry, 76(5):E660-E61.
Kagan S, Koruc Z, Latifoglu G (2017). Comparison of Psychological and Physiological Changes of the Anxiety in Various Sports. Rev Cercet Interv So, 56:44-56.
Castren E (2005). Opinion - is mood chemistry? Nat Rev Neurosci, 6(3):241-46.
Zis AP, Goodwin FK (1979). Novel anti-depressants and the biogenic-amine hypothesis of depression - case for iprindole and mianserin. Arch Gen Psychiatry, 36(10):1097-107.
Coppen A, Shaw DM, Malleson A (1965). Changes in 5-hydroxytryptophan metabolism in depression. Brit J Psychiat, 111(470):105-07.
Bystritsky A, Kerwin L, Feusner JD, et al. (2008). A pilot controlled trial of bupropion xl versus escitalopram in generalized anxiety disorder. Psychopharmacol Bull, 41(1):46-51.
Shimizu E, Hashimoto K, Okamura N, et al. (2003). Alterations of serum levels of brain-derived neurotrophic factor (bdnf) in depressed patients with or without antidepressants. Biol Psychiatry, 54(1):70-75.
Karege F, Perret G, Bondolfi G, et al. (2002). Decreased serum brain-derived neurotrophic factor levels in major depressed patients. Psychiatry Res, 109(2):143-48.
Lee HY, Kim YK (2008). Plasma brain-derived neurotrophic factor as a peripheral marker for the action mechanism of antidepressants. Neuropsychobiology, 57(4):194-99.
Brown MJ, Jacobs DE (2011). Residential light and risk for depression and falls: Results from the lares study of eight european cities. Public Health Rep, 126:131-40.
Murase S, Murase S, Kitabatake M, et al. (1995). Seasonal mood variation among japanese residents of stockholm. Acta Psychiatr Scand, 92(1):51-55.
Berman SM, Clear RD (2008). Past vision studies can support a novel human photoreceptor. Light Eng, 16(2):88-94.