Investigation of the Effects of Antibiotic Application on the Intestinal Flora in Elderly Hypertension Patients with Infectious Diseases
AbstractBackground: This study aimed to investigate the effects of antibiotic application on the intestinal flora in elderly hypertension patients with infectious diseases.Methods: A total of 2350 infected patients treated in Ordos Central Hospital (Inner Mongolia, China) from January 2010 to August 2016 were retrospectively analyzed and 790 healthy hypertension patients were selected as the control group. The 2350 patients were assigned into group A and B based on the administration with narrow-spectrum antibiotic or broad-spectrum antibiotic. The feces specimens of patients at the 1st, 5th, 9th and 14th day after antibiotic treatment were collected to analyze the bacteriological data and the cases of intestinal flora imbalance after applying the narrow-spectrum and broad-spectrum antibiotic were compared and the differences in the bacterial colony compositions of intestinal floras from those of the healthy hypertension patients at the same period were analyzed.Results: The ratio of intestinal flora imbalance was 50.4% after applying antibiotic in patients from group A and 78.3% in group B. grade I and II imbalance were predominant in group A and grade III imbalance was the most severe one in group B (P<0.05). Compared with the intestinal flora in healthy elderly hypertension patients, the ratio of the primary composition flora of patients with imbalanced intestinal flora was changed obviously.Conclusion: The application of narrow-spectrum antibiotic and shortening the application time of antibiotic can more effectively protect the normal intestinal flora of elderly hypertension patients.
Solomon SL, Oliver KB (2014). Antibiotic resistance threats in the United States: stepping back from the brink. Am Fam Physician, 89: 938-941.
Laxminarayan R, Duse A, Wattal C et al (2013). Antibiotic resistance—the need for global solutions. Lancet Infect Dis, 13: 1057-1098.
Hill M (1993). Probiotics: the scientific basis. Gut, 34(6): 863–864.
Kamada N, Chen GY, Inohara N, Núñez G (2013). Control of pathogens and pathobionts by the gut microbiota. Nat Immunol, 14: 685-690.
Clemente JC, Ursell LK, Parfrey LW, Knight R (2012). The impact of the gut microbiota on human health: an inte-grative view. Cell, 148: 1258-1270.
Magiorakos AP, Srinivasan A, Carey RB et al (2012). Multidrug‐resistant, extensively drug‐resistant and pandrug‐resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect, 18: 268-281.
Tuddenham S, Sears CL (2015). The Intes-tinal Microbiome and Health. Curr Opin Infect Dis, 28: 464–470.
Kostidis S, Kokova D, Dementeva N, Sal-tykova IV, Kim HK, Choi YH, Maybo-roda OA (2017). 1H-NMR Analysis of Feces: New Possibilities in the Hel-minthes Infections Research. BMC Infect Dis, 17: 275.
Nicholson JK, Holmes E, Kinross J et al (2012). Host-gut microbiota metabolic interactions. Science 336: 1262-1267.
D'Aversa F, Tortora A, Ianiro G et al (2013). Gut microbiota and metabolic syndrome. Intern Emerg Med, 1: S11-S15.
Holland KT, Knappc JS and Shoesmithc JG (1988). Anaerobic bacteria. Q Rev Biol, 27: 1031-1033.
Malaguarnera G, Leggio F, Vacante M et al (2012). Probiotics in the gastrointestinal diseases of the elderly. J Nutr Health Aging, 16: 402-410.
Biagi E, Candela M, Turroni S, Garagnani P, Franceschi C, Brigidi P (2013). Ageing and gut microbes: perspectives for health maintenance and longevity. Pharmacol Res, 69: 11-20.
American Diabetes Association (2014). Standards of medical care in diabetes—2014. Diabetes Care,37 Suppl 1:S14-80.
Yi B, Huang G, Zhou Z (2016). Different Role of Zinc Transporter 8 between Type 1 Diabetes Mellitus and Type 2 Diabetes Mellitus. J Diabetes Investig, 7: 459–465.
Yu H, Chen K, Wu J, Yang Z et al (2015). Identification of Toxemia in Patients with Clostridium Difficile Infection. PLoS One, 10: e0124235.
Yang T, Santisteban MM, Rodriguez V et al (2015). Gut dysbiosis is linked to hy-pertension. Hypertension, 65: 1331-1340.
Feng XB, Jiang J, Li M, Wang G, You JW, Zuo J (2016). Role of intestinal flora imbalance in pathogenesis of pouchitis. Asian Pac J Trop Med, 9: 786-90.
Qi Y, Aranda JM, Rodriguez V, Raizada MK, Pepine CJ (2015). Impact of antibiotics on arterialblood pressure in a patient with resistanthypertension - A case report. Int J Cardiol, 201: 157-158.
Barszcz M, Taciak M, Skomiał J (2016). The effects of inulin, dried Jerusalem artichoke tuber and a multispecies probiotic preparation on microbiota ecology and immune status of the large intestine in young pigs. Arch Anim Nutr, 70: 278-292.
Forslund K, Sunagawa S, Kultima JR, Mende DR, Arumugam M, Typas A, Bork P (2013). Country-specific antibiotic use practices impact the human gut resistome. Genome Res, 23: 1163-1169.
Berrilli F, Di Cave D, Cavallero S, D'Amelio S (2012). Interactions between parasites and microbial communities in the human gut. Front Cell Infect Microbiol, 2: 141.
Le Chatelier E, Nielsen T, Qin J et al (2013). Richness of human gut microbiome correlates with metabolic markers. Nature, 500: 541-546.