Medicinal Properties of Adiantum capillus-veneris Linn. in Traditional Medicine and Modern Phytotherapy: A Review Article
Abstract
Background: Adiantum capillus-veneris Linn (Maidenhair fern) is an herb belonging to the family Pteridaceae. It is named as “Pare-siavashan” in medical and pharmaceutical textbooks of Iranian Traditional Medicine. The fronds of Maidenhair fern were mainly administrated by ancient physicians as single medicine or in combination with other plants in multi-herbal formulations for curing different diseases. Because of different chemical compositions, the herb fronds were also assessed for its numerous pharmacological effects. Therefore, the current study was done to review the traditional usage and modern pharmacological and toxicological effects of Maidenhair fern.
Methods: Scientific databases and publications including Web of Science, PubMed, Scopus, Science direct, Cochrane Library, SID (for Persian papers) and medical and pharmaceutical textbooks of traditional medicine as well were searched for “Adiantum capillus-veneris”, “Maidenhair fern” and “Pare-siavashan” without limitation up to 2016.
Results: Maidenhair fern exhibited to possess anti-diabetic, anticonvulsant, analgesic, hypocholesterolemic, goitrogenic, anti-thyroidal, antibacterial, antifungal, wound healing, antiobesity, anti hair loss, anti-asthmatic, anti-inflammatory, antidiarrheal and antispasmodic, antioxidant as well as diuretic, anti-urolithiatic and detoxifying effects in modern medicine. Ancient physicians declared some of the confirmed pharmacological effects.
Conclusion: Maidenhair fern frond can be a good candidate for clinical purpose. Therefore, future researches on the other mentioned effects in traditional medicine are recommended.
The Plant List [database on the Internet] (2013). http://www.theplantlist.org/
LH. Evaluation of Antibacterial, Antioxidant and Toxicological Activity of Crude Extracts of Adiantum capillus-veneris, Blumea lacera, Cassia alata, and Cissus quadrangularis. BRAC, Department of Mathematics and Natural Sciences; 2011.
Gruenwald J, Brendler T, Jaenicke C (2008). PDR for herbal medicines. Montvale: Medical Economics Company.
Ibn Sina AAH (2005). Al Qanun Fi al-Tibb (Canon of medicine) [in Arabic]. Beirut: Alamy Le- Al-Matbooat Institute.
Rhazes (2005). Al Havi (Liber Continent). Tehran: Academy of Medical Sciences.
Shirazi ZA (1992). Ikhtiyarat‑e‑ Badiyee (Selections for Badii). Tehran: pakhsh razi press.
Aghili Khorasani Shirazi MH (1992). Makhzan ol Advieh (The Storehouse of Medicaments). Tehran: Tehran University of Medical Sciences. Sahba Press.
Arzani MA (2008). Teb e Akbari ( Akbari's medicine). Tehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine.
Khodaie L, Esnaashari S, Bamdad Moghaddam S (2015). Essential Oil of Arial Parts of Adiantum capillus-veneris: Chemical Composition and Antioxidant Activity. J Nat Pharm Prod, 10(4):3-7.
Nakane T, Maeda Y, Ebihara H et al (2002). Fern constituents: triterpenoids from Adiantum capillus-veneris. Chem Pharm Bull (Tokyo), 50(9):1273-5.
Nakane T, Arai Y, Masuda K et al (1999). Fern Constituents: Six New Triterpenoid Alcohols from Adiantum capillus-veneris. Chem Pharm Bull, 47(4):543-47.
Haider S, Kharbanda C, Alam MS et al (2013). Anti-inflammatory and anti-nociceptive activities of two new triterpenoids from Adiantum capillus-veneris Linn. Nat Prod Res, 27(24):2304-10.
Kumar S, Samydurai P, Ramakrishnan R, Nagarajan N (2014). Gas chromatography and mass spectrometry analysis of bioactive constituents of Adiantum capillus-veneris L. Int J Pharm Pharm Sci, 6(4):60-63.
Imperato F (1982). kaempferol 3-sulphate in the fern adiantum capillus-veneris. Phytochemistry, 21(1):2158-59.
Tonekaboni H (2007). Tohfat ol momenin. Tehran: Nashre shahr Press.
Jorjani SI (1976). Zakhireh Kharazmshahi (Treasures of the Khwarazm Shah). Tehran: Iranian Cultural Organisation Press.
Khorasani A (1855). Qarabadin kabir [in persian]. Tehran: OstadAllah qoli khan qajar publisher.
Esfehani HS (1383). Qarabadin Shafaie [in persian]. Tehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine.
Azam khan M (1869). Exir Azam (Great Elixir) [in Persian]. India: Monshi Nou.
Ranjan V, Vats M, Gupta N, Sardana S (2014). Antidiabetic potential of whole plant of Adiantum capillus veneris linn. in streptozotocin induced diabetic rats. IJPCR, 6(4):341-47.
Sultan AH, Dizaye KF, Hiwa B B (2012). Histological , Immunocytochemical and Biochemical Study of the Effect of Adiantum Capillus on Alloxan Induced Diabetic Rats. MEJIM, 5:3-12.
Kasabri V, Al-Hallaq E, Bustanji Y et al (2017). Antiobesity and antihyperglycaemic effects of Adiantum capillus-veneris extracts: in vitro and in vivo evaluations. Pharm Biol, 55(1):164-172.
Jain SK, Singh T, Pande M, Nema N (2014). Neuropharmacological screening of fronds of Adiantum capillus veneris linn. Pharm Lett, 6(3):167-75.
Chimie RRD, Al-hallaq EK, Litescu SC et al (2015). Hypocholesterolemic Effects of Adiantum Capillus Veneris L . aqueous extract in high Cholesterol diet-fed rats and hplc-ms determination of its polyphenolics. Rev Roum Chim, 60(4):357-65.
Vijayalakshmi A, Kiran Kumar Y (2013). Evaluation of goitrogenic and antithyroidal effect of the fern Adiantum capillus-veneris. Rev Bras Farmacogn, 23(5):802-10.
Medrar Hussain M, Ahmad B, Rashid E et al (2014). In vitro antibacterial activity of methanol and water extracts of Adiantum capillus veneris and tagetes patula against multidrug resistant bacterial strains. Pak J Bot, 46(1):363-68.
Shirazi MH, Amin G, Lavasani BA, Eshraghi SS (2011). Study of antibacterial properties of Adiantum capillus-veneris extract on eight species of gram positive and negative bacteria. J Med Plants, 10(40):124-32.
Guha P, Mukhopadhyay R, Pal PK, Gupta K (2004). Antimicrobial activity of crude extracts and extracted phenols from gametophyte and sporophytic plant parts of Adiantum capillus-veneris L. Allelopath J, 1:57-66.
Besharat M, Rahimian M, Ghaemi E, Besharat S (2009). Effect of ethanolic extract of Adiantum capillus-veneris in comparison with Gentamicine on 3 pathogenic bacteria in vitro. Pharm Sci, 15(1):49-52.
Ishaq MS, Hussain MM, Afridi MS et al (2014). In vitro phytochemical, antibacterial, and antifungal activities of leaf, stem, and root extracts of Adiantum capillus veneris. ScientificWorldJournal, 2014:269793.
Nilforoushzadeh MA, Javanmard SH, Ghanadian M (2014). The Effects of Adiantum capillus ‑ veneris on wound healing : An experimental in vitro evaluation. Int J Prev Med, 5(10):1261-8.
Galehdari H, Negahdari S, Kesmati M, Rezaie A, Shariati G (2016). Effect of the herbal mixture composed of Aloe Vera, Henna, Adiantum capillus-veneris, and Myrrha on wound healing in streptozotocin-induced diabetic rats. BMC Complement Altern Med, 16:386.
Noubarani M, Rostamkhani H, Erfan M et al (2014). Effect of Adiantum capillus veneris linn on an animal model of testosterone-induced hair loss. Iran J Pharm Res, 13(Suppl):113-8.
Jiang M-z, Yan H, Wen Y, Li X-m (2011). In vitro and in vivo studies of antioxidant activities of flavonoids from Adiantum capillus-veneris L. Afr J Pharm Pharmacol, 5(18):2079-85.
Kumar A (2009). Antioxidant Effect of Adiantum Capillus Veneris Linn . on human lymphocyte : an in vitro study. J Cell Tissue Res, 9:1899-902.
Sinam G, Behera SK, Mishra RK et al (2012). Comparison of two ferns (Adiantum Capillus-Veneris Linn. and Microsorium Punctatum (Linn.) Copel) for their cr accumulation potential and antioxidant responses. Int J Phytoremediation, 14(7):629-42.
Yuan QY, Ruan JL, Cai YL (2010). Effect of water extracts of Adiantum capillus-veneris L. on urinary tract infections. Chin Pharm J, 45(18):1389-92.
Ahmed A, Wadud A, Jahan N et al (2013). Efficacy of Adiantum capillus veneris Linn in chemically induced urolithiasis in rats. J Ethnopharmacol, 146(1):411-16.
Ahmed A, Bilal A, Hajera S, Jahan N, Wadud A (2013). In vitro effect of hydro alcoholic extract of Adiantum capillus-veneris Linn. on calcium oxalate crystallization. IJGP, 7(2):106-110.
Haider S, Nazreen S, Alam MM et al (2011). Anti-inflammatory and anti-nociceptive activities of ethanolic extract and its various fractions from Adiantum capillus veneris Linn. J Ethnopharmacol, 138(3):741-47.
Yuan Q, Zhang X, Liu Z et al (2013). Ethanol extract of Adiantum capillus-veneris L. suppresses the production of inflammatory mediators by inhibiting NF-κB activation. J Ethnopharmacol, 147(3):603-11.
Janbaz KH, Hassan W, Mehmood MH, Gilani AH (2015). Antidiarrheal and antispasmodic activities of adiantum capillus veneris L. Bangladesh J Pharmacol, 10(1):222-29.
Swaroop Kumar K, Anbu J, Anjana A et al (2012). Influence of ethanolic leaf extract of Sargassum wightii and Adiantum capillus on histamine induced asthma in animal model. Int J Pharm Pharm Sci, 4(Suppl 4):121-23.
Yousaf B, Amina, Liu G et al (2016). Bisphenol A exposure and healing effects of Adiantum capillus-veneris L. plant extract (APE) in bisphenol A-induced reproductive toxicity in albino rats. Environ Sci Pollut Res Int, 23(12):11645-57.
Kanchan G (2013). Protective effect of Adiantum capillus against chemically induced oxidative stress by cisplatin. J Appl Pharm Sci, 3(2):65-68.
Alwan AH, Al-Gaillany KAS, Naji A (1989). Inhibition of the binding of 3 h-benzo [a] pyrene to rat liver microsomal protein by plant extracts. Int J Crude Drug Res, 27(1):33-37.
Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D (2005). A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol, 99(3):317-24.
Trial RC, Qasemzadeh MJ, Sharifi H (2015). The effect of Viola odorata flower syrup on the cough of children with asthma. J Evid Based Complementary Altern Med, 20(4):287-91.
Sutovska M, Nosalova G, Franova S, Kardosova A (2007). The antitussive activity of polysaccharides from Althaea officinalis L., var. Robusta, Arctium lappa L., var. Herkules, and Prunus persica L., Batsch. Bratisl Lek Listy, 108(2):93-9.
Rabini S, Fink C, Kelber O et al (2015). Patient survey with Althaea officinalis L. root extract in dry cough. Eur J Integr Med, 7:46-47.
Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S (2014). Phytopharmacological overview of Tribulus terrestris. Pharmacogn Rev, 8(15):45-51.
Sowbhagya HB (2014). Chemistry, technology, and nutraceutical functions of celery (Apium graveolens L.): an overview. Crit Rev Food Sci Nutr, 54(3):389-98.
Yazdi A, Sardari S, Sayyah M, Hassanpour M (2011). Evaluation of the Anticonvulsant Activity of the Leaves of Glycyrrhiza glabra var . glandulifera grown in Iran , as a possible renewable source for anticonvulsant compounds. Iran J Pharm Res, 10(1):75-82.
Jafri MA, Ahmad M, Javed K, Singh S (1998). Antiasthmatic and antiinflammatory studies of Zoofae Yabis (Hyssopus officinalis). Naunyn Schmiedebergs Arch Pharmacol, 358(1):27-29.
Badgujar SB, Patel VV, Bandivdekar AH (2014). Foeniculum vulgare Mill : A review of Its botany, phytochemistry, pharmacology, contempo-rary application , and toxicology. Biomed Res Int, 2014:842674.
Rahim R, Ebadi N, Farjadmand F et al (2016). Adiantum Capillus Veneris L.: From Iranian Traditional Medicine to Modern Phytotherapy. Trad Integr Med, 1(3):129-31.
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| Issue | Vol 47 No 2 (2018) | |
| Section | Review Article(s) | |
| Keywords | ||
| Adiantum capillus-veneris Linn Maidenhair fern Phytotherapy Traditional medicine | ||
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