Dioxin Exposure in the Manufacture of Pesticide Production as a Risk Factor for Death from Prostate Cancer: A Meta-analysis
AbstractBackground: In pesticide exposure groups such as farmers, the risk of prostate cancer was increased, although the report of the cause of evidence is limited. We selected chlorophenol compounds as an important group of the contaminated pesticide with highly toxic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD). This meta-analysis, the risk of death from prostate cancer was analyzed.Methods: PubMed, Scopus, Scholar Google and web of Sciences until 2016 were searched. The standardized mortality rate (SMR) and 95% confidence intervals (CI) were obtained from the studies. We tested statistical heterogeneity with Cochrane Q test and I2 index. Egger test was used for evaluating publication bias. Random or fixed-effects models and meta-regression were also used in our analysis. Moreover, Cochrane tool was used to assess the risk of bias.Results: Five available papers consist of 28706 exposed populations were assessed. Overall standardized mortality rate as combined result of prostate cancer risk from the fixed model was 1.2 (95% confidence interval (CI) 1.02 to 1.42, P=0.027). Some biases are more probable in these studies such as confounding by indication, loss to follow up and misclassification.Conclusion: A contaminated pesticide with dioxins between other pesticides is an important risk factor for prostate cancers.
Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM (2010). Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer, 127(12): 2893-2917.
Siegel R, Naishadham D, Jemal A (2012). Cancer statistics. CA Cancer J Clin, 62(1): 10-29.
Bapat V (2008). Molecular Genetic Etiology of Prostate Cancer. Open Genomics J, 1: 13-21.
Fritschi L, Glass DC, Tabrizi JS, Leavy JE, Ambrosini GL (2006). Occupational risk factors for prostate cancer and benign prostatic hyperplasia: a case-control study in Western Australia. Occup Environ Med,64(1): 60-65.
Chen C, Xun P, Nishijo M, Carter S, He K (2016). Cadmium exposure and risk of prostate cancer: a meta-analysis of cohort and case-control studies among the general and occupational populations. Sci Rep, 6:25814.
Bunya N, Sawamoto K, Benoit H, Bird SB (2016). The Effect of Parathion on Red Blood Cell Acetylcholinesterase in the Wistar Rat. J Toxicol, 2016:1-6.
Choudhary N, Goyal R, Joshi SC (2008). Effect of malathion on reproductive system of male rats. J Environ Biol, 29(2): 259-262.
Mnif, W., Hassine A, Bouaziz A, Bartegi A, Thomas O, Roig B (2011). Effect of Endocrine Disruptor Pesticides: A Review. Int J Environ Res Public Health,8(6): 2265-2303.
Alvarez A, Benimeli CS, Saez JM et al (2012). Bacterial Bio-Resources for Remediation of Hexachlorocyclohexane. Int J Mol Sci, 13(11): 15086-15106.
Stackelberg K (2013). A Systematic Review of Carcinogenic Outcomes and Potential Mechanisms from Exposure to 2,4-D and MCPA in the Environment. J Toxicol, 2013:371610.
Igbinosa EO, Odjadjare EE, Chigor VN et al (2013). Toxicological Profile of Chlorophen-ols and Their Derivatives in the Environment: The Public Health Perspective. ScientificWorldJournal, 2013: 460215.
Sorg O, Zennegg M, Schmid P et al (2009). 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) poisoning in Victor Yushchenko: identifi cation and measurement of TCDD metabolites. Lancet, 374(9696):1179-85.
Steenland K, Bertazzi P, Baccarelli A, Kogevinas M (2004). Dioxin Revisited: Developments Since the 1997 IARC Classification of Dioxin as a Human Carcinogen. Environ Health Perspect,112(13): 1265-1268.
Bruner-Tran KL. Osteen KG (2011). Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations. Reprod Toxicol, 31(3): 344-350.
Koga T, Ishida T, Takeda T et al (2012). Restoration of Dioxin-Induced Damage to Fetal Steroidogenesis and Gonadotropin Formation by Maternal Co-Treatment with α-Lipoic Acid. PLoS One, 7(7):e40322.
Penel N ,Grosjean J, Marie Robin Y et al (2008). Frequency of Certain Established Risk Factors in Soft Tissue Sarcomas in Adults: A Prospective Descriptive Study of 658 Cases. Sarcoma, 2008: 1-6.
Bond GG, Wetterstroem NH, Roush GJ, McLaren EA, Lipps TE, Cook RR (1998). Cause specific mortality among employees engaged in the manufacture, formulation, or packaging of 2,4-dichlorophenoxyacetic acid and related salts. Br J Ind Med,45: 98-105.
Collins JJ, Bodner K, Aylward LL, Wilken M, Bodnar CM (2009). Mortality Rates Among Trichlorophenol Workers With Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin. Am J Epidemiol, 170(4): 501-506.
Ruder AM, Yiin JH (2011). Mortality of US pentachlorophenol production workers through 2005. Chemosphere, 83(6): 851-861.
Collins JJ, Bodner K, Aylward LL, Wilken M, Swaen G, Budinsky R, Rowlands C, Bodnar CM (2009). Mortality Rates Among Workers Exposed to Dioxins in the Manufacture of Pentachlorophenol. J Occup Environ Med , 51(10): 1212-1219.
Coggon D, Pannett B, Winter PD (1986). Mortality of workers exposed to 2 methyl-4 chlorophenoxyacetic acid. Scand J Work Environ Health, 12(5): 448-454.
Manz A, Berger J, Dwyer JH et al (1991). Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet,338: 959-64.
Fingerhut MA, Halperin WE, Marlow DA et al (1991). Cancer mortality in workers exposed to 2,3,7,8-tetrachlorodibenzo-P-Dioxine. N Engl J Med, 24: 212-218.
Becher H1, Flesch-Janys D, Kauppinen T et al (1996). Cancer mortality in German male workers exposed to phenoxy herbicides and dioxins. Cancer Causes Control , 7: 312-321.
Bueno de Mesquita HB, Doornbos G, Van der Kuip DA, Kogevinas M, Winkelmann R (1994). Occupational Exposure to Phenoxy Herbicides and Chlorophenols and Cancer Mortality in The Netherlands. Am J Ind Med, 23: 289-300.
Lynge E (1985). A follow-up study of cancer incidence among workers in manufacture of phenoxy herbicides in Denmark. Br J Cancer,52: 259-270.
Manolis Kogevinas H.B,Benn T, Bertazzi PA, Boffetta P (1997). Cancer Mortality in Workers Exposed to Phenoxy Herbicides, Chlorophenols, and Dioxins. Am J Epidemiol, 145(12):1-10.
Manuwald U, Velasco Garrido M, Berger J, Manz A,Baur X (2012). Mortality study of chemical workers exposed to dioxins: follow-up 23 years after chemical plant closure. Occup Environ Med, 69:636–642.
Burns CJ, Beard KK, Cartmill JB (2001). Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945–94: an update. Occup Environ Med, 58: 24–30.
Van Maele-Fabry G, Wilems JL (2003). Occupation related pesticide exposure and cancer of the prostate: a meta-analysis. Occup Environ Med ,60:634–642.
Camille Ragin, Brionna Davis-Reyes, Helina Tadesse (2013). Farming, Reported Pesticide Use, and Prostate Cancer. Am J Mens Health, 7(2): 102-109.
Gupta A1, Ketchum N, Roehrborn CG (2006). Serum Dioxin, Testosterone and Subsequent Risk of Benign Prostatic Hyperplasia: a Prospective Cohort Study of Air Force Veterans. Environ Health Perspect, 114(11):1649-54.
Kim J1, Wu D, Hwang DJ, Miller DD, Dalton JT (2005). The Para Substituent of S-3-(Phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides Is a Major Structural Determinant of in Vivo Disposition and Activity of Selective Androgen Receptor Modulatorsm. J Pharmacol Exp Ther, 315(1): 230–239.
Sabbota AL, Kim HR, Zhe X et al (2010). Shedding of RANKL by tumor-associated MT1-MMP activates Src-dependent prostate cancer cell migration. Cancer Res,70(13):5558-5566.