Mild Hypothermia Therapy for Moderate or Severe Hypoxic-ischemic Encephalopathy in Neonates
AbstractAbstract Background: To study the nursing method of mild hypothermia therapy for moderate or severe hypoxic-ischemic encephalopathy (HIE) in neonates. Methods: According to the inclusion and exclusion criteria, 48 patients were selected from Nanfang Hospital from December 2015 to October 2016 and randomly divided into the control group (n=24) and observation group (n=24). The control group received routine treatment and nursing, while the observation group received the same treatment as the control group combined with mild hypothermia treatment and nursing. The clinical effects were compared. Results: The total effective rate in the observation group was increased and mortality was decreased, and the differences were statistically significant (P=0.029 and 0.033, respectively). The 28 d neonatal behavioral neurological assessment and nursing satisfaction scores in the observation group were higher than those in the control group, and the differences were statistically significant (P=0.017 and 0.008, respectively). Conclusion: Mild hypothermia therapy for moderate or severe HIE in neonates is safe and effective, and the correct nursing method is important for guaranteeing proper clinical treatment.
Ahearne CE, Denihan NM, Walsh BH et al (2016). Early Cord Metabolite Index and Outcome in Perinatal Asphyxia and Hypoxic-Ischaemic Encephalopathy. Neonatology, 110: 296-302.
Chalia M, Lee CW, Dempsey LA et al (2016). Hemodynamic response to burst-suppressed and discontinuous electroen-cephalography activity in infants with hypoxic ischemic encephalopathy. Neurophotonics, 3: 031408.
Rasmussen LA, Bell E, Racine E (2016). A Qualitative Study of Physician Perspec-tives on Prognostication in Neona-tal Hypoxic Ischemic Encephalopathy. J Child Neurol, 31(11):1312-9.
Lafuente H, Pazos MR, Alvarez A, Mo-hammed N, Santos M, Arizti M, Alvarez FJ, Martinez-Orgado JA (2016). Effects of Cannabidiol and Hypothermia on Short-Term Brain Damage in New-Born Piglets after Acute Hypoxia-Ischemia. Front Neurosci, 10: 323.
Reinboth BS, Köster C, Abberger H, Prager S, Bendix I, Felderhoff-Müser U, Herz J (2016). Endogenous hypothermic re-sponse to hypoxia reduces brain injury: Implications for modelinghypoxic-ischemic encephalopathy and therapeu-tic hypothermia in neonatal mice. Exp Neurol, 283: 264-275.
Shankaran S, Natarajan G, Chalak L, Pappas A, McDonald SA, Laptook AR (2016). Hypothermia for neonatal hypoxic-ischemic encephalopathy: NICHD Neo-natal Research Network contribution to the field. Semin Perinatol, 40(6):385-390.
Silva AB, Laszczyk J, Wrobel LC, Ribeiro FL, Nowak AJ (2016). A thermoregula-tion model for hypothermic treatment of neonates. Med Eng Phys, 38(9):988-98.
Thorsen P, Jansen-van der Weide MC, Groenendaal F et al (2016). The Thomp-son Encephalopathy Score and Short-Term Outcomes in Asphyxiated New-borns Treated With Therapeu-tic Hypothermia. Pediatr Neurol, 60: 49-53.
Fredly S, Nygaard CS, Skranes JH, Stiris T, Fugelseth D (2016). Cooling Effect on Skin Microcirculation in Asphyxiated Newborn Infants with Increased C-Reactive Protein. Neonatology, 110: 270-276.
Saito J, Shibasaki J, Shimokaze T, Kishigami M, Ohyama M, Hoshino R, Toyoshima K, Itani Y (2016). Temporal relationship between serum levels of interleukin-6 and c-reactive protein in therapeutic hypo-thermia for neonatal hypoxic-ischemic encephalopathy. Am J Perinatol, 33(14):1401-1406.
Nespeca M, Giorgetti C, Nobile S, Ferrini I, Simonato M, Verlato G, Cogo P, Carnielli VP (2016). Does Whole-Body Hypothermia in Neonates with Hypoxic-Ischemic Encephalopathy Affect Surfactant Disaturated-Phosphatidylcholine Kinetics? PLoS One, 11: e0153328.
Zhang Y, Zhang JL, Li Y (2016). Computed tomography diagnosis of neona-tal hypoxic ischemic encephalopa-thy combined with intracranial hemor-rhage and clinical nursing treatment. J Biol Regul Homeost Agents, 30: 511-515.
Wietstock SO, Bonifacio SL, McCulloch CE, Kuzniewicz MW, Glass HC (2015). Neo-natal Neurocritical Care Service Is Associ-ated With Decreased Administration of Seizure Medication. J Child Neurol, 30: 1135-1141.
Wang MM, Wang MH (2013). Neonatal as-phyxia: a care experience using hypo-thermic therapy. Hu Li Za Zhi, 60: 103-109.
Guidotti I, Lugli L, Guerra MP, Ori L, Gallo C, Cavalleri F, Ranzi A, Frassoldati R, Berardi A, Ferrari F (2016). Hypothermia reduces seizure burden and improves neurological outcome in severe hypoxic-ischemic encephalopathy: an observa-tional study. Dev Med Child Neurol, 58(12):1235-1241.
Wu YW, Mathur AM, Chang T et al (2016). High-Dose Erythropoietin and Hypothermia for Hypoxic-Ischemic Encephalopathy: A Phase II Trial. Pediat-rics, 137(6). pii: e20160191.
Elbahtiti A, Aly NY, Abo-Lila R, Al-Sawan R (2016). Therapeutic hypothermia for in-fants with hypoxic ischemic encephalopa-thy: A five years' single center experience in Kuwait. J Neonatal Perinatal Med, 9(2): 179-185.
Merrill L (2012). Therapeutic hypothermia to treat hypoxic ischemic encephalopathy in newborns: implications for nurses. Nurs Womens Health, 16: 126-134.
Chirinian N, Mann N (2011). Therapeutic hypothermia for management of neona-tal asphyxia: What nurses need to know. Critical Care Nurse, 31(3): e1-12.
Higgins RD, Raju TN, Perlman J et al. (2006). Hypothermia and perinatal as-phyxia: Executive summary of the Na-tional Institute of Child Health and Hu-man Development workshop. J Pediatr, 184: 170-175.