Factors Determining Effective Orthokeratology Treatment for Controlling Juvenile Myopia Progression

  • Qinghui KONG Dept. of Ophthalmology, Shenzhen Second Hospital, Shenzhen, Guangdong, China
  • Jiang GUO Dept. of Ophthalmology, Shenzhen Second Hospital, Shenzhen, Guangdong, China
  • Jing ZHOU Dept. of Ophthalmology, Shenzhen Second Hospital, Shenzhen, Guangdong, China
  • Yanling ZHANG Dept. of Teaching and Research, School of Medical Technology and Nursing, Shenzhen, Guangdong, China
  • Xiaoyan DOU Dept. of Ophthalmology, Shenzhen Second Hospital, Shenzhen, Guangdong, China
Keywords: Orthokeratology, Myopia, Retrospective analysis, Logistic regression analysis


Background: We aimed to identify factors influencing the therapeutic outcome of orthokeratology on controlling juvenile myopia progression, and the risk factors for complications. Methods: Myopic patients (n=724) in Shenzhen Second Hospital from Jan 2011 to Jan 2016 fitted with orthokeratology lenses and followed-up for 6–65 months were reviewed retrospectively. Univariate and multivariate logistic regression analyses were used to screen for the factors that can improve treatment outcome and prevent the development of complications. Results: Patients where the orthokeratology treatment was effective displayed a shorter myopia time, smaller diopter and corneal curvature, larger corneal endothelium density, high proportion of overnight wear and longer wearing times compared with patients whose treatments were ineffective. Additionally, wearing Ortho-k for 6 or 12 months yielded improved corrective effect and achieved higher comfort level. Logistic regression analyses showed that myopia time, diopter, corneal curvature e value, corneal endothelium density, time with Ortho-k and corrective effect after wearing Ortho-k for 6 or 12 months were all independent factors influencing the treatment effects. Results showed corneal curvature, anterior chamber depth and central corneal thickness were independent risk factors. Conclusion: This study systematically identified the factors leading to effective treatments, and those carrying a risk for complications, to provide guidance for the prescription and follow-up of orthokeratology in the treatment of juvenile myopia.   


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How to Cite
KONG Q, GUO J, ZHOU J, ZHANG Y, DOU X. Factors Determining Effective Orthokeratology Treatment for Controlling Juvenile Myopia Progression. Iran J Public Health. 46(9):1217-1222.
Original Article(s)