Iranian Journal of Public Health 2017. 46(9):1211-1216.

The Relationship between Type 2 Diabetes and Platelet Indicators
Xiangyu CHEN, Le FANG, Hongbo LIN, Peng SHEN, Tao ZHANG, Hui LI, Xiaoyong LI, Min YU, Chunxiao XU, Jie ZHANG, Feng LU, Xiaofu DU, Ruying HU, Jieming ZHONG



Background: Currently, the studies on the relationship between type 2 diabetes and platelets indicators were carried out on a selective small sample population generally. Large sample studies in this area are rare, especially in Chinese population. In this study, we aimed to investigate the relationship between type 2 diabetes and the mean platelet volume (MPV), platelet count (PLT) and platelet distribution width (PDW).

Methods: This is a cross-sectional analysis of the routine health examination data from 20128 participants with complete baseline data in Yinzhou District 2013. The detection of indicators in this study was completed by automatic hematology analyzer.

Results: The PDW and PLT were not significantly different between diabetic group and non-diabetic group, (16.00% vs. 16.00%, P=0.88, and 194*109/L vs. 196*109/L, P=0.05 respectively). The MPV was significantly higher in diabetic group (9.3fl vs. 9.2fl, P<0.05). MPV was an independent risk factor of diabetes mellitus (Unadjusted OR=1.07 (95% CI: 1.03, 1.11), Adjusted for age, sex OR=1.07 (95% CI: 1.02, 1.12)). The adjusted odds ratio of diabetes rose with increasing MPV levels and were most pronounced in subjects with MPV levels exceeding the 90th percentile (MPV≥10.70 fl, Crude or=1.23 adjusted or=1.19).

Conclusion: There was no relationship between the presence of diabetes with PDW and PLT. The MPV was independently associated with the presence of diabetes.



Diabetes mellitus, Mean platelet volume, Platelet distribution width, Platelet count

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Shah B, Sha D, Xie D, et al (2012). The Relationship Between Diabetes, Metabolic Syndrome, and Platelet Activity as Measured by Mean Platelet Volume The National Health and Nutrition Examination Survey, 1999–2004. Diabetes Care, 35(5): 1074-8.

Zuberi B, Akhtar N, Afsar S (2008). Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singapore Med J, 49(2): 114-6.

Zahavi J, Zahavi M, Firsteter E, et al (1991). An abnormal pattern of multiple platelet function abnormalities and increased thromboxane generation in patients with primary thrombocytosis and thrombotic complications. Eur J Haematol, 47(5): 326-332.

Davi G, Patrono C, Catalano I, et al (1993). Inhibition of thromboxane biosynthesis and platelet function by indobufen in type II diabetes mellitus. Arterioscler Thromb, 13(9): 1346-9.

Jindal S, Gupta S, Gupta R, et al (2011). Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology, 16(2):86-9.

Mustand J, Packham M (1984). Platelets and diabetes mellitus. N Engl J Med, 311:665-667.

Xu Y, Wang L, He J, et al (2013). Prevalence and control of diabetes in Chinese adults. JAMA, 310(9): 948-59.

Ates O, Kiki I, Bilen H, et al (2009). Association of mean platelet volume with the degree of retinopathy in patients with diabetes mellitus. Eur J Gen Med, 6(2):99–102.

Lumley T, Diehr P, Emerson S, et al (2002). The importance of the normality assumption in large public health data sets. Annu Rev Public Health, 23: 151-69.

Saigo K, Yasunaga M, Ryo R, et al (1992). Mean platelet volume in diabetics. Rinsho Byori, 40(2): 215-7.

Hekimsoy Z, Payzin B, Ornek T, Kandoğan G (2004). Mean platelet volume in Type 2 diabetic patients. J Diabetes Complications, 18(3):173-6.

Martyn CN, Matthews DM, Popp-Snijders C, et al (1986). Effects of sorbinil treatment on erythrocytes and platelets of persons with diabetes. Diabetes Care.9:36–9

Watanabe Y, Kawada M, Kobayashi B (1987). Effect of insulin on murine megakaryocy-topoiesis in a liquid culture system. Cell Struct Funct, 12(3):311–16.


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